Effect of urea liquid fertilizer spraying at different plant growth stages on grain yield and protein content in Sardari dryland wheat was studied. During the investigation, 50 kg/ha of nitrogen (N) for all treatments was applied in autumn as early nitrogen application, then the experiment was continued in a randomized complete block design (RCBD) with 6 treatments for later spring application, (%5 N solution by spraying on the basis of 20 kg N.ha’ in tillering, shooting, flag leaf, flowering time and liquid urea spraying (5% N) along with 2 litr.ha’ of herebicide 2,4,D in tillering stage as well as in control). The experiment (with 3 replications) was carried out for three cropping years (1998-2001) in Maragheh Dryland Agricultural Research Station. The results indicated that urea solution spraying (%5 N) relatively increased grain yield.The highest average grain yield occurred at flowering stage with 14% increase as compared to control. Protein content, similar to grain yield, increased substantially through urea spraying. The highest protein content, %17.7 was obtained at shooting, and tillering (with 2,4,D) stages as compared to control. The greatest effective treatment was urea application along with 2,4,D at tillering stage, which increased both protein content as well as grain yield as compared to other treatments. It can be concluded that liquid urea spraying increases protein content in dryland wheat grain. Application of N solution along with 2,4,D increases protein content when applied at tillering stage.