The effects of different N rates and plant densities on yield and yield components in two sesame (Sesame indicum L.) cultivars were evaluated in a factorial experiment (2 ?3?3) arranged in a randomized complete block design with four replications. Plant densities consisted of 10.0, 16.6 and 25.0 plants m-2 and nitrogen rates were 0, 60, and 90 kg ha-1. The two sesame cultivars were Zarghan local and Darab 14. Nitrogen (N) rates exhibited a significant effect on number of branches per plant, capsules per plant, seed and protein percentage content. Plant density had also a significant effect on seed yield, biological yield, harvest index, number of branches per plant, and number of capsules per plant. Increasing N rates along with plant density increased seed yield with the highest yield (1724 kg/ha) and harvest index being obtained in Zarghan cultivar, while using 90 kg N/ha at 25.0 plants per m2 with no significant difference being observed as with 60 kg N/ha. Application of 90 kg N/ha caused an increase in protein accumulation by 25% as compared to control (no fertilizer). Seed oil percentage was a stable yield component and was not affected by either N rates or plant density. Maximum oil percentage was obtained in Darab 14 cultivar, when using 90 kg N ha-1 and 10 plants per m2. Zarghan cultivar was superior as for N fertilizer, plant density, and seed yield, but in Darab 14 cultivar higher oil and protein percentages were produced.