A poultry meat producer would prefer more male birds due to more economic returns. Different approaches have been designed to alter sex ratio, from which administration of Aromatase inhibitor is one. The present study was conducted to compare the relative potencies of two different anti-aromatase (at various levels) in chicken sex determination. A number of 525 eggs were divided into 7 groups. On day 5, eggs were treated with single injections of either 14- ? hydroxy androstone 3, 6, 17- trione (NKSO1), (1 and 2 mg) or Fadrazole (0.05, 0.1, and 0.15 mg). All hatched chickens were then reared for 7 weeks to study their general economic performances. The results indicate that, as compared to NKSO1, 0.1 mg Fadrazol resulted in a significant increase in male birds (p<0.05). In ovo injection of Fadrazol there appeared no negative effects on either hatchability, chick viability, and/or economic performances such as feed effeciency, live weight and carcass cuts, though, males significatly (p<0.01) outhumbered females over the given period. In conclusion, it clear seems that altering sex ratio, for production of more males would greately enhance the broiler industry`s profits and therfore would be quickly developed to be employed in commercial application.