Chemical control of weeds in corn is not extensively studied in Isfahan. Thus, the effectiveness of preplanting application of atrazine (3.2 and 0.9 kg a.i. ha-1) and eradicane (4.8 kg a.i. ha-1), postemergence application of 2A-D (1.4 kg a.i. ha-1) and a combination of these herbicides for control of weeds in corn were studied in 1993 at the Agricultural Research Station, Isfahan University of Technology, using a randomized complete block design with ten treatments and four replications. An untreated plot was considered as check. Arnaranthus ret roflexus, Echinochloa crus galli, chenopodium album and Convulvolus arvensis were the predominant weeds. Solanum nigrum, Setaria Viridis, Lepidium draba, Trthuius urestris, Portulaa oleracea and Eragrostis sp. were of lower importance. Combination of eradicane, 0.9 kg a.i. ha-1’ of atrazine and 2,4-D effectively controlled Amaranthus retroflexus. Preplant application of. eradicane satisfactorily controlled Echinocloa crus ga/li during the whole growing season. A mixture of 3.2 kg a.i. ha-1 atrazine and eradicane was the most effective treatment in reducing the number and dry weight of weeds at the early season. 2,4-D effectively controlled the broad-leaved weeds that had escaped preplant treatments, but increased the competition of grasses. It seems that combination of 4.8 kg a.i. ha-1 eradicane, 0.9 kg a.i. ha-1 atrazine and 1.4 kg a.i. ha-1 2,4-D is the best treatment for weed control in corn under conditions similar to this experiment.